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[av_heading heading=’Neuroblastoma’ tag=’h1′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote’ size=’60’ subheading_active=’subheading_below’ subheading_size=’15’ margin=” margin_sync=’true’ padding=’10’ color=” custom_font=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-kirxeipx’ admin_preview_bg=”]
The Facts, Reality & Stories of Childhood Cancer
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[av_image src=’https://isabellasantosfoundation.org/wp-content/uploads/2023/02/banner-isabella.jpg’ attachment=’19208′ attachment_size=’full’ copyright=” caption=” image_size=” styling=’no-styling’ box_shadow=’none’ box_shadow_width=’10’ box_shadow_color=” align=’center’ font_size=” overlay_opacity=’0.4′ overlay_color=’#000000′ overlay_text_color=’#ffffff’ animation=’no-animation’ animation_duration=” animation_custom_bg_color=” animation_z_index_curtain=’100′ parallax_parallax=” parallax_parallax_speed=” av-desktop-parallax_parallax=” av-desktop-parallax_parallax_speed=” av-medium-parallax_parallax=” av-medium-parallax_parallax_speed=” av-small-parallax_parallax=” av-small-parallax_parallax_speed=” av-mini-parallax_parallax=” av-mini-parallax_parallax_speed=” hover=” blur_image=” grayscale_image=” fade_image=” appearance=” css_position=” css_position_location=’,,,’ css_position_z_index=” av-desktop-css_position=” av-desktop-css_position_location=’,,,’ av-desktop-css_position_z_index=” av-medium-css_position=” av-medium-css_position_location=’,,,’ av-medium-css_position_z_index=” av-small-css_position=” av-small-css_position_location=’,,,’ av-small-css_position_z_index=” av-mini-css_position=” av-mini-css_position_location=’,,,’ av-mini-css_position_z_index=” transform_perspective=” transform_rotation=’,,,’ transform_scale=’,,’ transform_skew=’,’ transform_translate=’,,’ av-desktop-transform_perspective=” av-desktop-transform_rotation=’,,,’ av-desktop-transform_scale=’,,’ av-desktop-transform_skew=’,’ av-desktop-transform_translate=’,,’ av-medium-transform_perspective=” av-medium-transform_rotation=’,,,’ av-medium-transform_scale=’,,’ av-medium-transform_skew=’,’ av-medium-transform_translate=’,,’ av-small-transform_perspective=” av-small-transform_rotation=’,,,’ av-small-transform_scale=’,,’ av-small-transform_skew=’,’ av-small-transform_translate=’,,’ av-mini-transform_perspective=” av-mini-transform_rotation=’,,,’ av-mini-transform_scale=’,,’ av-mini-transform_skew=’,’ av-mini-transform_translate=’,,’ mask_overlay=” mask_overlay_shape=’blob’ mask_overlay_size=’contain’ mask_overlay_scale=’100%’ mask_overlay_position=’center center’ mask_overlay_repeat=’no-repeat’ mask_overlay_rotate=” mask_overlay_rad_shape=’circle’ mask_overlay_rad_position=’center center’ mask_overlay_opacity1=’0′ mask_overlay_opacity2=’1′ mask_overlay_opacity3=” link=” target=” title_attr=” alt_attr=” img_scrset=” lazy_loading=’disabled’ id=” custom_class=” template_class=” element_template=” one_element_template=” av_element_hidden_in_editor=’0′ av_uid=’av-ledf03ny’ sc_version=’1.0′ admin_preview_bg=”][/av_image]

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Pictured: Isabella | Neuroblastoma | 2005-2012

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[av_one_full first min_height=” vertical_alignment=’av-align-top’ space=” row_boxshadow=” row_boxshadow_width=’10’ row_boxshadow_color=” custom_margin=” margin=’0px’ av-desktop-margin=” av-medium-margin=” av-small-margin=” av-mini-margin=” mobile_breaking=” mobile_column_order=” border=” border_style=’solid’ border_color=” radius=” min_col_height=” padding=” av-desktop-padding=” av-medium-padding=” av-small-padding=” av-mini-padding=” svg_div_top=” svg_div_top_color=’#333333′ svg_div_top_width=’100′ svg_div_top_height=’50’ svg_div_top_max_height=’none’ svg_div_top_flip=” svg_div_top_invert=” svg_div_top_front=” svg_div_top_opacity=” svg_div_top_preview=” svg_div_bottom=” svg_div_bottom_color=’#333333′ svg_div_bottom_width=’100′ svg_div_bottom_height=’50’ svg_div_bottom_max_height=’none’ svg_div_bottom_flip=” svg_div_bottom_invert=” svg_div_bottom_front=” svg_div_bottom_opacity=” svg_div_bottom_preview=” column_boxshadow=” column_boxshadow_width=’10’ column_boxshadow_color=” background=’bg_color’ background_color=” background_gradient_direction=’vertical’ background_gradient_color1=’#000000′ background_gradient_color2=’#ffffff’ background_gradient_color3=” src=” background_position=’top left’ background_repeat=’no-repeat’ highlight=” highlight_size=” animation=” animation_duration=” animation_custom_bg_color=” animation_z_index_curtain=’100′ parallax_parallax=” parallax_parallax_speed=” av-desktop-parallax_parallax=” av-desktop-parallax_parallax_speed=” av-medium-parallax_parallax=” av-medium-parallax_parallax_speed=” av-small-parallax_parallax=” av-small-parallax_parallax_speed=” av-mini-parallax_parallax=” av-mini-parallax_parallax_speed=” css_position=” css_position_location=” css_position_z_index=” av-desktop-css_position=” av-desktop-css_position_location=” av-desktop-css_position_z_index=” av-medium-css_position=” av-medium-css_position_location=” av-medium-css_position_z_index=” av-small-css_position=” av-small-css_position_location=” av-small-css_position_z_index=” av-mini-css_position=” av-mini-css_position_location=” av-mini-css_position_z_index=” link=” linktarget=” link_hover=” title_attr=” alt_attr=” mobile_display=” mobile_col_pos=’0′ id=” custom_class=” template_class=” aria_label=” element_template=” one_element_template=” show_locked_options_fakearg=” av_uid=’av-1uylq’ sc_version=’1.0′]

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Neuroblastoma is a type of solid tumor that occurs in the developing cells of the sympathetic nervous system. The sympathetic nervous system is a nerve network that carries messages throughout the body. Sympathetic nerves are responsible for actions of the body that are not under voluntary control, such as increasing heart rate, blushing, and dilating the pupils of the eye. Neuroblastoma begins when a change or mutation occurs in a young cell of the sympathetic nervous system, known as a neuroblast. The change allows neuroblasts to grow uncontrollably and form cancerous tumors. Neuroblastoma can begin anywhere in the body, but is most commonly found in the adrenal gland, located on top of the kidney. Other common locations for neuroblastoma include the neck, chest, abdomen, and pelvis, near the spine. Neuroblastoma can spread to other areas of the body, including the bone marrow, bones, and lymph nodes. Neuroblastoma usually occurs in infants and young children. It is uncommon in older children and teenagers. About 7 out of every 100 children with cancer will have neuroblastoma.

The Isabella Santos Foundation (ISF) is committed to improving rare pediatric cancer treatment options in an effort to increase the survival rates of kids with cancer so they can live their dreams.  Our partnership with Levine Children’s Hospital funds The Isabella Santos Foundation Rare & Solid Tumor Program to provide the most comprehensive care and treatments for pediatric cancer in our community and across the globe. This clinic will offer the most advanced clinical treatments, including precision medicine and novel clinical trials, to bring forward the newest therapies and improve outcomes in childhood cancer.
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[av_heading heading=’Childhood Cancer – The Facts and Reality’ tag=’h2′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=” subheading_active=’subheading_below’ subheading_size=’15’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-1q4zq’]
Cancer is the leading cause of death by disease among U.S. children.
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[av_tab title=’The Facts’ icon_select=’no’ icon=’ue800′ font=’entypo-fontello’ custom_id=” av_uid=’av-1jj3u’ sc_version=’1.0′]

  • Neuroblastoma affects approximately 800 children a year and is most commonly found in children under the age of 5.
  • Neuroblastoma is a rare cancer of the sympathetic nervous system, a nerve network that carries messages from the brain throughout the body.
  • Most neuroblastoma begins in the abdomen in the adrenal gland, next to the spinal cord, or in the chest.
  • Neuroblastoma can spread to the bones, bone marrow, brain, spine, liver, lymph nodes, skin, and around the eyes.
  • Neuroblastoma has one of the lowest survival rates of all pediatric cancers and accounts for 15% of all pediatric cancer deaths. The first symptoms are often vague and may include fatigue and loss of appetite which is why it can be hard to diagnose.
  • 70% of cases at diagnosis have already spread to other areas of the body which places the cancer in a Stage 4 category.
  • The 5-year survival rate for high-risk Neuroblastoma is 50%.
  • The 5-year survival rate for children with low-risk Neuroblastoma is 95%
  • The 5-year survival rate for children with intermediate Neuroblastoma is 90%-95%
  • 60% of patients with high-risk Neuroblastoma will relapse. Once in relapse, the survival rate drops to less than 5%.
  • There are no known cures for relapsed Neuroblastoma.
  • Neuroblastoma has one of the lowest survival rates of all pediatric cancers and accounts for 15% of all pediatric cancer deaths.

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[av_tab title=’The Reality’ icon_select=’no’ icon=’ue800′ font=’entypo-fontello’ av_uid=’av-14m2i’ custom_id=” sc_version=’1.0′]

  • Childhood cancers, like Neuroblastoma, fall into the rare category.
  • There will be approximately 10,380 new cases of pediatric cancer diagnosed in children under 15 in 2015;
  • Cancer is the leading cause of death by disease among U.S. children and the second leading cause of death in children (after accidents)
  • The National Cancer Institute’s (NCI) investment in pediatric cancers was $195.5 million in 2011, while its investment for breast cancer research that year was $625 million.
  • About 1,250 children younger than 15 years old are expected to die from cancer in 2015.
  • Approximately half of the oncology drugs to treat children are at least 20 years old.
  • A large part of the funding for Neuroblastoma treatments, and other rare pediatric cancers, are made possible through private institutions, generous donors, and families of children with Neuroblastoma.

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[av_heading heading=’Stories of Neuroblastoma’ tag=’h2′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=” subheading_active=” subheading_size=’15’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-zs2m’][/av_heading]

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It started with a girl… and she is changing the world…

On March 9th, 2005, Isabella Joanne Santos came into the world.  Her first two years were filled with memories and milestones just like every other child.  In the summer of 2007, she began to complain of frequent back and stomach pain.  After months of misdiagnosis, an MRI revealed a tumor in her abdomen and showed the disease had spread to her bone marrow.  On October 4, 2007, she was diagnosed with stage 4 high-risk neuroblastoma.
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