Torch

Fueling Progress in Pediatric Cancer Care

The TORCH (Transformational Outcomes for Rare Cancer Heroes) Initiative is a bold extension of the Isabella Santos Foundation’s (ISF) legacy, dedicated to improving both the quantity and quality of life for young rare cancer patients beyond Charlotte.

TORCH Funding Priorities

Clinical Trials

Expanding access to cutting-edge treatments for rare pediatric cancers.

Basic Science Research

Unlocking breakthroughs in cancer therapies through innovative scientific discovery.

Survivorship Support

Enhancing long-term care and quality of life beyond treatment.

Home Hospital Needs

Addressing critical gaps in pediatric cancer care at hospitals serving rare cancer patients.

2024-2025 TORCH Recipients

Following a rigorous review process by a distinguished scientific committee, six outstanding institutions were selected to receive grants aimed at transforming pediatric cancer care. 

Novant Health (Charlotte, NC)

Funding supports two impactful initiatives for rare cancer patients:

Mental Health Services: Offering counseling to address the emotional challenges of a cancer diagnosis.

Whole-Foods Nutrition Program: Providing nutrient-rich meals to enhance healing, reduce side effects, and improve treatment outcomes.
Together, these initiatives address emotional and physical well-being, fostering resilience and a better quality of life.

Duke University School of Medicine (Durham, NC)

In partnership with Atrium Health, funding will be utilized to make osteosarcoma treatment easier and safer by testing if patients can leave the hospital sooner after receiving a key chemotherapy drug, potentially reducing hospital stays and costs while maintaining safety. Additionally, it explores the use of organoids to study tumor resistance and identify new therapeutic opportunities.

UNC Medical Center (Chapel Hill, NC)

Funding advances research on CAR T-cell therapy for rare brain tumors, focusing on lab testing to ensure effective treatments before administering them to patients. This innovative approach aims to improve survival rates and reduce the physical and emotional toll on children, revolutionizing brain tumor care.

Mission Hospital (Asheville, NC)

Two essential programs are being expanded to improve pediatric cancer patients’ quality of life:

Beads of Courage Program: An evidence-based therapy fostering resilience and positive coping strategies.

Therapeutic Sensory Program: Incorporating calming technologies like LED Bubble Tubes and Sensate Soundscapes in treatment areas to reduce stress and anxiety.

Children’s Healthcare of Atlanta (Atlanta, GA)

Funding supports the development of immune-based therapies for osteosarcoma, leveraging advanced genetic techniques to study cancer cell vulnerabilities. Researchers aim to boost the immune system and develop new therapies, potentially leading to clinical trials for pediatric bone cancer.

Texas Children’s Hospital (Houston, TX)

Funding enhances a promising treatment for neuroblastoma, improving natural killer T cells (NKTs) through advanced research. By refining proteins and manufacturing processes, this initiative aims to create more effective and scalable therapies, revolutionizing pediatric cancer treatment.

TORCH Initiative Grant Application Timeline & Guidelines

Each year, we invite pediatric hospitals and research institutions to submit proposals that drive progress in clinical trials, survivorship programs and groundbreaking therapies.

Letters of Intent (LOIs) must be submitted by June 1. Following review, selected applicants will be invited to submit a full Request for Proposal (RFP), which will be due no later than August 15. 

All proposals undergo a rigorous review process by a distinguished scientific committee composed of leading experts in pediatric oncology. Submissions will be evaluated based on innovation, feasibility and potential impact on advancing rare pediatric cancer research and treatment.

View Sample Letter of Intent

  • Proposals should align with the mission of TORCH: improving both the quality and quantity of life for children with rare cancers.
  • Eligible projects may include clinical trials, basic science research, survivorship support or fulfilling a home hospital’s greatest needs.
  • Applicants must provide a detailed project plan, budget and measurable outcomes.
  • Selected recipients will be expected to provide progress updates and demonstrate the impact of the funded project.

For full application guidelines and submission requirements, please reach out to info@isftorch.org.

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Stay in Touch

For general inquiries, contact us at info@isftorch.org.