When I started the Isabella Santos Foundation (ISF), my goal was clear: fight for all children battling rare cancers. It was a decision born from my heart, because every child I’ve met over the years deserved the same hope and opportunity as Isabella.

For years, ISF has funded programs and research that may not have directly helped Isabella, but they were the right things to do—they made a difference for other kids. Now, after years of hard work and determination, I’m thrilled to share that we’re achieving something next-level extraordinary.

While we will continue to fund boots-on-the-ground programs that help children and families in our community, our newly launched TORCH (Transformational Outcomes for Rare Cancer Heroes) Initiative will advance life-changing research, clinical trials, and survivorship programs at eight of the nation’s leading children’s hospitals in 2025. This includes a $250,000 grant to neuroblastoma research – our first time funding groundbreaking neuroblastoma science that brings hope to families like ours. Science that could have saved Isabella’s life.

But we need your help to take this further.

A generous donor has issued a challenge: If we raise $100,000 by December 18th, they will match it at 150%. This is BIG.

Your donation today will:

• Expand programs that fund immediate needs and ensure brighter tomorrows for children in Charlotte and beyond.
• Fund innovative science that delivers real hope to families.
• Support clinical trials that bring cutting-edge treatments to children.

This matching challenge is an incredible opportunity to make an impact, but we can’t do it without you.

When you donate to ISF, you’re helping fund the science that saves lives, the trials that deliver hope, and the programs that lift up children and families in need. You’re choosing Isabella’s legacy, and you’re ensuring her mission continues to inspire and transform lives.

Every gift matters, every minute counts. Will you rise to the challenge and help us make the most of this incredible opportunity?

Thank you from the bottom of our hearts,

💜 Erin, Grant, and Sophia
Executive Director, Isabella Santos Foundation