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[av_heading heading=’Grow Hair’ tag=’h1′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote’ size=’70’ subheading_active=’subheading_below’ subheading_size=’15’ margin=” margin_sync=’true’ padding=’10’ color=” custom_font=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-k6ipzwoy’ admin_preview_bg=”]
Improving Pediatric Cancer Trials & Studies | 20% of Mission Focus
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Pictured: Gracie | Undifferentiated Sarcoma

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[av_heading heading=’IMPROVING TRIALS AND STUDIES
FOR BETTER OUTCOMES’ tag=’h2′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=’30’ subheading_active=’subheading_below’ subheading_size=’20’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-2n1qqqn’]
Strengthening Treatments for Rare Pediatric Cancers
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Kids fighting cancer desperately need safer and more effective cancer treatments. The funds raised through the Grow Hair giving program is 20% of our mission focus and will be granted to national institutions, supporting clinical trials. The goal is to provide more options for those fighting.

In 2021, ISF helped fund two clinical trials…

  1. Levine Children’s Enrolls Patient in Innovative Pediatric Oncology Trial
  2. 2. ISF kicks off funding for neuroblastoma & sarcoma clinical trial at Levine Children’s (more to come in 2022)

Over the course of our foundation, ISF has donated $1,953,635 to fund national trials and studies focused on rare childhood cancers.
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[av_heading heading=’Nationwide Children’s, The TINKS Trial’ tag=’h3′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=’30’ subheading_active=’subheading_below’ subheading_size=’20’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-65d9jz’]
Tribute to Madison Fedak,Osteosarcoma
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[av_heading heading=’Children’s Oncology Group, Rhabdomyosarcoma Data Study’ tag=’h3′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=’30’ subheading_active=’subheading_below’ subheading_size=’20’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-19tbau7′]
Tribute to Merritt Plummer, Rhabdomyosarcoma
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[av_testimonial_single src=” name=’Aaron’ subtitle=’Merritt’s Dad’ link=’http://’ linktext=” av_uid=’av-oqkhi7′]
“The toll chemo drugs takes on Merritt’s little body is awful.  The worst has been the chemo burn she gets in her diaper area after certain drugs.  Not being potty trained makes it to where we have to change her diaper every 45 minutes for 12-24 hours after chemo to keep it from burning her so bad.  It gets so bad at times that one week we went through 14 tubes of Desitin diaper rash cream and 4 tubes of prescription diaper rash cream.”
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[av_heading heading=’ISF FUNDED TRIALS AND STUDIES’ tag=’h2′ link_apply=” link=’manually,http://’ link_target=” style=’blockquote modern-quote modern-centered’ size=’30’ subheading_active=’subheading_below’ subheading_size=’20’ margin=” padding=’10’ color=” custom_font=” custom_class=” admin_preview_bg=” av-desktop-hide=” av-medium-hide=” av-small-hide=” av-mini-hide=” av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” av_uid=’av-wteqin’]
National
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  • Nationwide Children’s Hospital:  The TINKS Trial, focused on creating a new way of treating kids fighting relapsed sarcomas (osteosarcoma, Ewing’s sarcoma, rhabdomyosarcoma)
  • Helen DeVos Children’s Hospital:  DFMO, a pilot clinical trial lead by Dr. Giselle Sholler for children with high-risk neuroblastoma. The trial introduced a new drug, DFMO, earlier in treatment combined with antibody therapy that is used to help prevent a relapse of Neuroblastoma. The trial will be available at participating hospitals, including Levine Children’s Hospital in Charlotte NC
  • Nationwide Children’s Hospital:  Neuroblastoma Killer Cell Trial & neuroblastoma research
  • Memorial Sloan Kettering Cancer Center:  SADA Drug Delivery Platform. The SADA drug delivery platform was created to control drug delivery with such precision that toxicity only occurs where the drug is picked up by tumor cells, and not to normal bone marrow, the immune system, kidney or other vital organs.
  • Memorial Sloan Kettering Cancer Center: Hu3F8 Clinical Trial.  This grant funded the clinical testing of a Hu3F8 bi-specific antibody targeted at neuroblastoma. Based on a previous trial’s finding, the Hu3F8 antibody has shown great promise as a delivery agent for drug treatments; during the trial, patients experienced more manageable side effects and were able to receive treatments more often providing a sustained anti-tumor response. (in collaboration through Band of Parents with Arms Wide Open Childhood Cancer Foundation, Inc., Press On to CURE Childhood Cancer Fund, and the I Back Jack Foundation)

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  • Children’s Oncology Group: Rhabdomyosarcoma data studyThis five-year trial is focused on analyzing tissue samples to assess patterns in rhabdomyosarcoma. The results will have significant effects on the treatment and prognosis of rhabdomyosarcoma patients now and in the future.
  • Children’s Oncology Group: Frontline MIBG Therapy, This Phase 3 trial was specifically targeted to determine the effectiveness of pulling MIBG therapy, which is traditionally used as an end of life treatment, to the frontline of therapy for children with high-risk neuroblastoma. This trial was available nationwide.
  • Children’s Oncology Group:  Circulating Tumor DNA project, technology developed within test tubes that will allow cancer to be detected through a blood test. Circulating tumor DNA may provide a method for monitoring disease status during treatment and maybe a means with which to detect changes in pediatric cancer mutation status without the need for invasive biopsies.
  • Children’s Oncology Group:  Project Every Child, a study to capture the biology and outcome of every child diagnosed with cancer in the United States. The ultimate goal is to collect biospecimens, including tumor tissue, host, and when feasible, parental DNA samples, which are stored at the COG’s state-of-the-art biorepository at Nationwide Children’s Hospital. These samples may then be utilized by any scientist in their studies to find new and improved cures for pediatric cancer.

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